Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis

Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis

Background and aim: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, with most patients succumbing rapidly after diagnosis. The mevalonate pathway, which is involved in the regulation of cell proliferation, survival, and motility, is targ...

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Bibliographic Details
Main Authors: Lloyd Tanner, Jesper Bergwik, Andrew B. Single, Ravi K. V. Bhongir, Jonas S. Erjefält, Arne Egesten
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
IPF
Zoledronic Acid
mevalonate
Fibrosis
FDPS
drug repurposing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.899469/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.899469/full

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