Generation and validation of an iPSC line (BBANTWi008-A) from a Loeys-Dietz Syndrome type 3 patient

Loeys-Dietz Syndrome (LDS) is an autosomal dominant connective tissue disorder. The major hallmark of LDS is thoracic aortic aneurysm and dissection (TAAD). We generated an induced pluripotent stem cell (iPSC) line of a severely affected LDS patient carrying a pathogenic SMAD3 p.Arg287Gln variant. P...

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Bibliographic Details
Main Authors: Joe Davis Velchev, Aline Verstraeten, Josephina Meester, Peter Ponsaerts, Julie Richer, Maaike Alaerts, Bart Loeys
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122002811