Deficiency in Retinal TGFβ Signaling Aggravates Neurodegeneration by Modulating Pro-Apoptotic and MAP Kinase Pathways

Deficiency in Retinal TGFβ Signaling Aggravates Neurodegeneration by Modulating Pro-Apoptotic and MAP Kinase Pathways

Transforming growth factor β (TGFβ) signaling has manifold functions such as regulation of cell growth, differentiation, migration, and apoptosis. Moreover, there is increasing evidence that it also acts in a neuroprotective manner. We recently showed that TGFβ receptor type 2 (<i>Tgfbr2</i...

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Bibliographic Details
Main Authors: Christina B. Bielmeier, Sabrina I. Schmitt, Nikolai Kleefeldt, Stefaniya K. Boneva, Anja Schlecht, Mario Vallon, Ernst R. Tamm, Jost Hillenkamp, Süleyman Ergün, Andreas Neueder, Barbara M. Braunger
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
TGFβ signaling
retina
retinitis pigmentosa
neuro-/photoreceptor degeneration
MAP kinase pathway
ferroptosis
Online Access:https://www.mdpi.com/1422-0067/23/5/2626

Internet

https://www.mdpi.com/1422-0067/23/5/2626

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