BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Abstract Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific manipulations, we discovered a novel GABAergic Purkinje cell (PC) circuit in the c...

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Bibliographic Details
Main Authors: Xiu-Xiu Liu, Xing-Hui Chen, Zhi-Wei Zheng, Qin Jiang, Chen Li, Lin Yang, Xiang Chen, Xing-Feng Mao, Hao-Yang Yuan, Li-Li Feng, Quan Jiang, Wei-Xing Shi, Takuya Sasaki, Kohji Fukunaga, Zhong Chen, Feng Han, Ying-Mei Lu
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00989-x

Internet

https://doi.org/10.1038/s41392-022-00989-x

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