Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients

Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients

BackgroundApart from bactericidal effects, anti-tuberculosis drugs can interfere with the host’s immune system. In this study, we analyzed the role of delamanid (DLM), an inhibitor of mycolic acid synthesis of mycobacterial cell wall, on human macrophages.MethodsBased on a cohort of multidrug-resist...

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Bibliographic Details
Main Authors: Min Qiao, Shanshan Li, Jinfeng Yuan, Weicong Ren, Yuanyuan Shang, Wei Wang, Rongmei Liu, Fuzhen Zhang, Qing Li, Xiao Wu, Jie Lu, Mengqiu Gao, Yu Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
delamanid
CXCL10
JAK/STAT1
tuberculosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.923492/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.923492/full

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