Astragaloside IV attenuates IL-1β-induced intervertebral disc degeneration through inhibition of the NF-κB pathway

Astragaloside IV attenuates IL-1β-induced intervertebral disc degeneration through inhibition of the NF-κB pathway

Abstract Background Intervertebral disc degeneration (IDD) is the main cause of low back pain. Patients with low back pain may experience significant socio-economic burdens and decreased productivity. Previous studies have shown that inflammation is one of the main causes of IDD. Astragaloside IV (A...

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Bibliographic Details
Main Authors: Yueyang Tian, Xu Chu, Qia Huang, Xing Guo, Yuan Xue, Weimin Deng
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Astragaloside IV
Intervertebral disc degeneration
NF-κB
Extracellular matrix
Inflammation
Apoptosis
Online Access:https://doi.org/10.1186/s13018-022-03438-1

Internet

https://doi.org/10.1186/s13018-022-03438-1

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