Screening method toward ClbP-specific inhibitors

Screening method toward ClbP-specific inhibitors

Abstract Background Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is the key enzyme for activation of colibactin. Inhibition of ClbP is c...

Full description

Bibliographic Details
Main Authors: Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Kenji Watanabe
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Genes and Environment
Subjects:
Colibactin
ClbP
Inhibitor
Screening
Fluorescent
Probe
Online Access:https://doi.org/10.1186/s41021-023-00264-7

Internet

https://doi.org/10.1186/s41021-023-00264-7

Similar Items