Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats

Background. Cholestasis is a sign of hepatic ischemia-reperfusion injury (IRI), which is caused by the dysfunction of hepatocyte membrane transporters (HMTs). As transcriptional regulation of HMTs during oxidative stress is mediated by nuclear factor erythroid 2-related factor 2, we hypothesized tha...

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Bibliographic Details
Main Authors: Joohyun Kim, MD, PhD, Catherine E. Hagen, MD, Suresh N. Kumar, PhD, Jong-In Park, PhD, Michael A. Zimmerman, MD, Johnny C. Hong, MD
Format: Article
Language:English
Published: Wolters Kluwer 2020-08-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001017