Extracellular Vesicle-Mediated Purinergic Signaling Contributes to Host Microenvironment Plasticity and Metastasis in Triple Negative Breast Cancer

Extracellular Vesicle-Mediated Purinergic Signaling Contributes to Host Microenvironment Plasticity and Metastasis in Triple Negative Breast Cancer

Metastasis accounts for over 90% of cancer-related deaths, yet the mechanisms guiding this process remain unclear. Secreted nucleoside diphosphate kinase A and B (NDPK) support breast cancer metastasis. Proteomic evidence confirms their presence in breast cancer-derived extracellular vesicles (EVs)....

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Bibliographic Details
Main Authors: Suzann Duan, Senny Nordmeier, Aidan E. Byrnes, Iain L. O. Buxton
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular vesicles
exosomes
purinergic signaling
nucleoside diphosphate kinase
angiogenesis
metastasis
Online Access:https://www.mdpi.com/1422-0067/22/2/597

Internet

https://www.mdpi.com/1422-0067/22/2/597

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