The Second-Generation XPO1 Inhibitor Eltanexor Inhibits Human Cytomegalovirus (HCMV) Replication and Promotes Type I Interferon Response

The Second-Generation XPO1 Inhibitor Eltanexor Inhibits Human Cytomegalovirus (HCMV) Replication and Promotes Type I Interferon Response

Human cytomegalovirus (HCMV) is a ubiquitous opportunistic pathogen and can be life-threatening for immunocompromised individuals. There is currently no available vaccine for the prevention of HCMV- associated diseases and most of the available antiviral drugs that target viral DNA synthesis become...

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Bibliographic Details
Main Authors: Yueyan Liao, Xiangyu Ke, Tianyi Deng, Qingsong Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
cytomegalovirus
type I interferon
replication
Eltanexor
XPO1 inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.675112/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.675112/full

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