Novel Doxorubicin Derivatives: Synthesis and Cytotoxicity Study in 2D and 3D in Vitro Models

Novel Doxorubicin Derivatives: Synthesis and Cytotoxicity Study in 2D and 3D in Vitro Models

Purpose: Multidrug resistance (MDR) of tumors to chemotherapeutics often leads to failure of cancer treatment. The aim of the study was to prepare novel MDR-overcoming chemotherapeutics based on doxorubicin (DOX) derivatives and to evaluate their efficacy in 2D and 3D in vitro models. Methods: To ov...

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Bibliographic Details
Main Authors: Roman Akasov, Maria Drozdova, Daria Zaytseva-Zotova, Maria Leko, Pavel Chelushkin, Annie Marc, Isabelle Chevalot, Sergey Burov, Natalia Klyachko, Thierry Vandamme, Elena Markvicheva
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2017-12-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Aantitumor drug screening assays
Microencapsulation
Multicellular spheroids
Multiple drug resistance
Serum albumin
Online Access:http://apb.tbzmed.ac.ir/PDF/apb-7-593.pdf

Internet

http://apb.tbzmed.ac.ir/PDF/apb-7-593.pdf

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