TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation
Tumor necrosis factor receptor 2 (TNFR2) has been shown to play a crucial role in CD4+ T regulatory cells (CD4+Tregs) expansion and suppressive function. Increasing evidence has also demonstrated its role in a variety of immune regulatory cell subtypes such as CD8+ T regulatory cells (CD8+ Tregs), B...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.903913/full |
| _version_ | 1828465428129644544 |
|---|---|
| author | Araz Kouyoumdjian Araz Kouyoumdjian Jean Tchervenkov Jean Tchervenkov Steven Paraskevas Steven Paraskevas |
| author_facet | Araz Kouyoumdjian Araz Kouyoumdjian Jean Tchervenkov Jean Tchervenkov Steven Paraskevas Steven Paraskevas |
| author_sort | Araz Kouyoumdjian |
| collection | DOAJ |
| description | Tumor necrosis factor receptor 2 (TNFR2) has been shown to play a crucial role in CD4+ T regulatory cells (CD4+Tregs) expansion and suppressive function. Increasing evidence has also demonstrated its role in a variety of immune regulatory cell subtypes such as CD8+ T regulatory cells (CD8+ Tregs), B regulatory cells (Bregs), and myeloid-derived suppressor cells (MDSCs). In solid organ transplantation, regulatory immune cells have been associated with decreased ischemia-reperfusion injury (IRI), improved graft survival, and improved overall outcomes. However, despite TNFR2 being studied in the context of autoimmune diseases, cancer, and hematopoietic stem cell transplantation, there remains paucity of data in the context of solid organ transplantation and islet cell transplantation. Interestingly, TNFR2 signaling has found a clinical application in islet transplantation which could guide its wider use. This article reviews the current literature on TNFR2 expression in immune modulatory cells as well as IRI, cell, and solid organ transplantation. Our results highlighted the positive impact of TNFR2 signaling especially in kidney and islet transplantation. However, further investigation of TNFR2 in all types of solid organ transplantation are required as well as dedicated studies on its therapeutic use during induction therapy or treatment of rejection. |
| first_indexed | 2024-12-11T03:32:47Z |
| format | Article |
| id | doaj.art-7050f161972c42659ed66d11bcff015e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T03:32:47Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7050f161972c42659ed66d11bcff015e2022-12-22T01:22:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.903913903913TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in TransplantationAraz Kouyoumdjian0Araz Kouyoumdjian1Jean Tchervenkov2Jean Tchervenkov3Steven Paraskevas4Steven Paraskevas5Division of Experimental Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, CanadaDivision of General Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaDivision of Experimental Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, CanadaDivision of General Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaDivision of Experimental Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, CanadaDivision of General Surgery, Department of Surgery, McGill University, Montreal, QC, CanadaTumor necrosis factor receptor 2 (TNFR2) has been shown to play a crucial role in CD4+ T regulatory cells (CD4+Tregs) expansion and suppressive function. Increasing evidence has also demonstrated its role in a variety of immune regulatory cell subtypes such as CD8+ T regulatory cells (CD8+ Tregs), B regulatory cells (Bregs), and myeloid-derived suppressor cells (MDSCs). In solid organ transplantation, regulatory immune cells have been associated with decreased ischemia-reperfusion injury (IRI), improved graft survival, and improved overall outcomes. However, despite TNFR2 being studied in the context of autoimmune diseases, cancer, and hematopoietic stem cell transplantation, there remains paucity of data in the context of solid organ transplantation and islet cell transplantation. Interestingly, TNFR2 signaling has found a clinical application in islet transplantation which could guide its wider use. This article reviews the current literature on TNFR2 expression in immune modulatory cells as well as IRI, cell, and solid organ transplantation. Our results highlighted the positive impact of TNFR2 signaling especially in kidney and islet transplantation. However, further investigation of TNFR2 in all types of solid organ transplantation are required as well as dedicated studies on its therapeutic use during induction therapy or treatment of rejection.https://www.frontiersin.org/articles/10.3389/fimmu.2022.903913/fullTNFR2immune regulationtransplantationrejectionischemia reperfusion injury (IRI) |
| spellingShingle | Araz Kouyoumdjian Araz Kouyoumdjian Jean Tchervenkov Jean Tchervenkov Steven Paraskevas Steven Paraskevas TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation Frontiers in Immunology TNFR2 immune regulation transplantation rejection ischemia reperfusion injury (IRI) |
| title | TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation |
| title_full | TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation |
| title_fullStr | TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation |
| title_full_unstemmed | TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation |
| title_short | TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation |
| title_sort | tfnr2 in ischemia reperfusion injury rejection and tolerance in transplantation |
| topic | TNFR2 immune regulation transplantation rejection ischemia reperfusion injury (IRI) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.903913/full |
| work_keys_str_mv | AT arazkouyoumdjian tfnr2inischemiareperfusioninjuryrejectionandtoleranceintransplantation AT arazkouyoumdjian tfnr2inischemiareperfusioninjuryrejectionandtoleranceintransplantation AT jeantchervenkov tfnr2inischemiareperfusioninjuryrejectionandtoleranceintransplantation AT jeantchervenkov tfnr2inischemiareperfusioninjuryrejectionandtoleranceintransplantation AT stevenparaskevas tfnr2inischemiareperfusioninjuryrejectionandtoleranceintransplantation AT stevenparaskevas tfnr2inischemiareperfusioninjuryrejectionandtoleranceintransplantation |