RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation

RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation

Abstract Glioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs) contributing to tumorigenesis and therapeutic resistance. Pharmacologic modulators of ubiquitin ligases and deubiquitinases are under development for c...

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Bibliographic Details
Main Authors: Peng Lin, Wenyan Chen, Zhilin Long, Jichuan Yu, Jiayao Yang, Zhen Xia, Qiulian Wu, Xinyu Min, Jing Tang, Ya Cui, Fuyi Liu, Chun Wang, Jian Zheng, Wei Li, Jeremy N. Rich, Lei Li, Qi Xie
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00654-3

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https://doi.org/10.1038/s41421-024-00654-3

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