Cell-Based HIF1α Gene Therapy Reduces Myocardial Scar and Enhances Angiopoietic Proteome, Transcriptomic and miRNA Expression in Experimental Chronic Left Ventricular Dysfunction

Cell-Based HIF1α Gene Therapy Reduces Myocardial Scar and Enhances Angiopoietic Proteome, Transcriptomic and miRNA Expression in Experimental Chronic Left Ventricular Dysfunction

Recent preclinical investigations and clinical trials with stem cells mostly studied bone-marrow-derived mononuclear cells (BM-MNCs), which so far failed to meet clinically significant functional study endpoints. BM-MNCs containing small proportions of stem cells provide little regenerative potentia...

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Bibliographic Details
Main Authors: Edit Gara, Sang-Ging Ong, Johannes Winkler, Katrin Zlabinger, Dominika Lukovic, Bela Merkely, Maximilian Y. Emmert, Petra Wolint, Simon P. Hoerstrup, Mariann Gyöngyösi, Joseph C. Wu, Noemi Pavo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
chronic ischemic heart failure
porcine infarction model
mesenchymal stem cells
minicircle vector
HIF1α
adverse remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.767985/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.767985/full

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