The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway

The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway

(+)-Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge <i>Aplysina aerophoba</i> that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and in vivo and modulating the redox status of different cell...

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Bibliographic Details
Main Authors: Isabel Vidal, Laura Castilla, Ana Dácil Marrero, Inés Bravo-Ruiz, Manuel Bernal, Inmaculada Manrique, Ana R. Quesada, Miguel Ángel Medina, Beatriz Martínez-Poveda
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Marine Drugs
Subjects:
aeroplysinin-1
marine-sponge-derived metabolites
endothelial cells
inflammation
NF-κB pathway
PI3K/Akt pathway
Online Access:https://www.mdpi.com/1660-3397/20/10/605

Internet

https://www.mdpi.com/1660-3397/20/10/605

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