Transcriptomic Analysis of the Effect of Metformin against Cisplatin-Induced Ototoxicity: A Potential Mechanism of Metformin-Mediated Inhibition of Thioredoxin-Interacting Protein (Txnip) Gene Expression

Transcriptomic Analysis of the Effect of Metformin against Cisplatin-Induced Ototoxicity: A Potential Mechanism of Metformin-Mediated Inhibition of Thioredoxin-Interacting Protein (Txnip) Gene Expression

Ototoxicity is the drug-induced damage of the inner ear, causing bilateral irreversible sensorineural hearing loss. Cisplatin is a widely used chemotherapeutic agent which causes ototoxicity as its side effect. Pretreatment with metformin prior to the application of cisplatin significantly decreased...

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Bibliographic Details
Main Authors: Sehee Lee, Sun Choi, Seok Hyun Park, Gi Jung Im, Jiwon Chang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Current Issues in Molecular Biology
Subjects:
cisplatin
ototoxicity
metformin
prevention
gene expression
Txnip pathway
Online Access:https://www.mdpi.com/1467-3045/45/1/21

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https://www.mdpi.com/1467-3045/45/1/21

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