A model of metformin mitochondrial metabolism in metachromatic leukodystrophy: first description of human Schwann cells transfected with CRISPR-Cas9

A model of metformin mitochondrial metabolism in metachromatic leukodystrophy: first description of human Schwann cells transfected with CRISPR-Cas9

Metachromatic leukodystrophy is a neurological lysosomal deposit disease that affects public health despite its low incidence in the population. Currently, few reports are available on pathophysiological events related to enzyme deficiencies and subsequent sulfatide accumulation. This research aims...

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Bibliographic Details
Main Authors: Nayibe Tatiana Sanchez-Álvarez, Paula Katherine Bautista-Niño, Juanita Trejos-Suárez, Norma Cecilia Serrano-Díaz
Format: Article
Language:English
Published: The Royal Society 2022-07-01
Series:Open Biology
Subjects:
metachromatic leukodystrophy (MLD)
metabolic activity
metformin
neurological lysosomal storage disease
sulfatide therapy
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210371

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.210371

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