From affinity selection to kinetic selection in Germinal Centre modelling.

From affinity selection to kinetic selection in Germinal Centre modelling.

Affinity maturation is an evolutionary process by which the affinity of antibodies (Abs) against specific antigens (Ags) increases through rounds of B-cell proliferation, somatic hypermutation, and positive selection in germinal centres (GC). The positive selection of B cells depends on affinity, bu...

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Bibliographic Details
Main Authors: Danial Lashgari, Elena Merino Tejero, Michael Meyer-Hermann, Mathieu A F Claireaux, Marit J van Gils, Huub C J Hoefsloot, Antoine H C van Kampen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010168

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https://doi.org/10.1371/journal.pcbi.1010168

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