A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations

A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations

The physiologically based pharmacokinetic modeling (PBPK) approach can predict drug pharmacokinetics (PK) by combining changes in blood flow and pathophysiological alterations for developing drug-disease models. Cefepime hydrochloride is a parenteral cephalosporin that is used to treat pneumonia, se...

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Bibliographic Details
Main Authors: Muhammad Talha Zahid, Ammara Zamir, Abdul Majeed, Imran Imran, Sary Alsanea, Tanveer Ahmad, Faleh Alqahtani, Muhammad Fawad Rasool
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Saudi Pharmaceutical Journal
Subjects:
Cefepime
Pharmacokinetics
Cephalosporin
Pediatrics
Chronic kidney disease
Obese
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423001603

Internet

http://www.sciencedirect.com/science/article/pii/S1319016423001603

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