Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

Summary: Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in the growth plate due to impaired HC apoptosis. Studies in HCs demonstrate that Pi activates the Raf/MEK/ERK1/2 and mitochondrial apoptotic pathways. To determine how Pi acti...

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Bibliographic Details
Main Authors: Prem Swaroop Yadav, Garyfallia Papaioannou, Margaret M. Kobelski, Marie B. Demay
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223016255

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223016255

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