Polymyxin B Combined with Minocycline: A Potentially Effective Combination against bla<sub>OXA-23</sub>-harboring CRAB in In Vitro PK/PD Model

Polymyxin B Combined with Minocycline: A Potentially Effective Combination against bla<sub>OXA-23</sub>-harboring CRAB in In Vitro PK/PD Model

Polymyxin-based combination therapy is commonly used to treat carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) infections. In the present study, the bactericidal effect of polymyxin B and minocycline combination was tested in three CRAB strains containing bla<sub>OXA-23&l...

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Bibliographic Details
Main Authors: Xingyi Qu, Xingchen Bian, Yuancheng Chen, Jiali Hu, Xiaolan Huang, Yu Wang, Yaxin Fan, Hailan Wu, Xin Li, Yi Li, Beining Guo, Xiaofen Liu, Jing Zhang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
<i>Acinetobacter baumannii</i>
polymyxin B
minocycline
combination therapy
in vitro pharmacokinetic/pharmacodynamic model
Online Access:https://www.mdpi.com/1420-3049/27/3/1085

Internet

https://www.mdpi.com/1420-3049/27/3/1085

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