Polymyxin B Combined with Minocycline: A Potentially Effective Combination against bla<sub>OXA-23</sub>-harboring CRAB in In Vitro PK/PD Model

Polymyxin B Combined with Minocycline: A Potentially Effective Combination against bla<sub>OXA-23</sub>-harboring CRAB in In Vitro PK/PD Model

Polymyxin-based combination therapy is commonly used to treat carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) infections. In the present study, the bactericidal effect of polymyxin B and minocycline combination was tested in three CRAB strains containing bla<sub>OXA-23&l...

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Bibliographic Details
Main Authors: Xingyi Qu, Xingchen Bian, Yuancheng Chen, Jiali Hu, Xiaolan Huang, Yu Wang, Yaxin Fan, Hailan Wu, Xin Li, Yi Li, Beining Guo, Xiaofen Liu, Jing Zhang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
<i>Acinetobacter baumannii</i>
polymyxin B
minocycline
combination therapy
in vitro pharmacokinetic/pharmacodynamic model
Online Access:https://www.mdpi.com/1420-3049/27/3/1085
Description
Summary:Polymyxin-based combination therapy is commonly used to treat carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) infections. In the present study, the bactericidal effect of polymyxin B and minocycline combination was tested in three CRAB strains containing bla<sub>OXA-23</sub> by the checkerboard assay and in vitro dynamic pharmacokinetics/pharmacodynamics (PK/PD) model. The combination showed synergistic or partial synergistic effect (fractional inhibitory concentration index ≤0.56) on the tested strains in checkboard assays. The antibacterial activity was enhanced in the combination group compared with either monotherapy in in vitro PK/PD model. The combination regimen (simultaneous infusion of 0.75 mg/kg polymyxin B and 100 mg minocycline via 2 h infusion) reduced bacterial colony counts by 0.9–3.5 log<sub>10</sub> colony forming units per milliliter (CFU/mL) compared with either drug alone at 24 h. In conclusion, 0.75 mg/kg polymyxin B combined with 100 mg minocycline via 2 h infusion could be a promising treatment option for CRAB bloodstream infections.
ISSN:1420-3049

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