S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720

S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720

Hyperactive sphingosine 1-phosphate (S1P) signaling is associated with a poor prognosis of triple-negative breast cancer (TNBC). Despite recent evidence that links the S1P receptor 1 (S1P1) to TNBC cell survival, its role in TNBC invasion and the underlying mechanisms remain elusive. Combining analy...

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Bibliographic Details
Main Authors: Fabrice J. F. Laroche, Sheng Li, Ning Shen, Soo Kyung Hwang, Gina Nguyen, Wenling Yu, Chen Khuan Wong, Ryan J. Quinton, Jason N. Berman, Ching-Ti Liu, Anurag Singh, Neil J. Ganem, Sam Thiagalingam, Hui Feng
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
triple-negative breast cancer
sphingosine 1-phosphate receptor 1
threonine 236 phosphorylation
invasiveness
zebrafish
MK2206
Online Access:https://www.mdpi.com/2073-4409/12/7/980

Internet

https://www.mdpi.com/2073-4409/12/7/980

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