A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death
Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known proinflammatory role, LPS can directly cause regression of some tumors, although the underlying mechanism has remained unknown. Here w...
Main Authors: | Shigetoshi Yokoyama, Yan Cai, Miyuki Murata, Takeshi Tomita, Mitsuhiro Yoneda, Lei Xu, Aprile L Pilon, Raul E Cachau, Shioko Kimura |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/37854 |
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