Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy

Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy

Recently, the <sup>1</sup>H-detected in-cell NMR spectroscopy has emerged as a unique tool allowing the characterization of interactions between nucleic acid-based targets and drug-like molecules in living human cells. Here, we assess the application potential of <sup>1</sup>...

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Bibliographic Details
Main Authors: Daniel Krafčík, Eva Ištvánková, Šimon Džatko, Pavlína Víšková, Silvie Foldynová-Trantírková, Lukáš Trantírek
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
in-cell NMR
G-quadruplex
ligand
drug
Bcl2
telomeric DNA
Online Access:https://www.mdpi.com/1422-0067/22/11/6042

Internet

https://www.mdpi.com/1422-0067/22/11/6042

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