Rational incorporation of any unnatural amino acid into proteins by machine learning on existing experimental proofs

Rational incorporation of any unnatural amino acid into proteins by machine learning on existing experimental proofs

The unnatural amino acid (UAA) incorporation technique through genetic code expansion has been extensively used in protein engineering for the last two decades. Mutations into UAAs offer more dimensions to tune protein structures and functions. However, the huge library of optional UAAs and various...

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Bibliographic Details
Main Authors: Haoran Zhang, Zhetao Zheng, Liangzhen Dong, Ningning Shi, Yuelin Yang, Hongmin Chen, Yuxuan Shen, Qing Xia
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Protein design
Unnatural amino acid incorporation
Genetic code expansion
Machine learning
Virtual screening
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702200397X

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http://www.sciencedirect.com/science/article/pii/S200103702200397X

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