Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice

Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice

Liver-specific deficiency of B-cell receptor-associated protein 31 knockout mice (BAP31-LKO) and the littermates were injected with acetaminophen (APAP), markers of liver injury, and the potential molecular mechanisms were determined. In response to APAP overdose, serum aspartate aminotransferase an...

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Bibliographic Details
Main Authors: Jie Zhao, Xiaotong Lv, Yan Huo, Xiaodi Hu, Xiaochen Li, Shizhuo Sun, Xin Zhao, Xuewei Kong, Jialin Xu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
BAP31
acetaminophen
oxidative stress
Nrf2
Online Access:https://www.mdpi.com/1422-0067/22/19/10788

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https://www.mdpi.com/1422-0067/22/19/10788

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