Low level of stromal lectin‐like oxidized LDL receptor 1 and CD8+ cytotoxic T‐lymphocytes indicate poor prognosis of colorectal cancer

Low level of stromal lectin‐like oxidized LDL receptor 1 and CD8+ cytotoxic T‐lymphocytes indicate poor prognosis of colorectal cancer

Abstract Background Lectin‐like oxidized LDL receptor‐1 (LOX‐1) has been identified as a new marker for functional myeloid‐derived suppressor cells (MDSCs) that exhibit an immunosuppressive phenotype in the tumor microenvironment (TME). However, the role of LOX‐1+ cells in the TME of colorectal canc...

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Bibliographic Details
Main Authors: Chika Katayama, Takehiko Yokobori, Naoya Ozawa, Kunihiko Suga, Takuya Shiraishi, Takuhisa Okada, Katsuya Osone, Ryuji Katoh, Toshinaga Suto, Yoko Motegi, Hiroomi Ogawa, Akihiko Sano, Makoto Sakai, Makoto Sohda, Bilguun Erkhem‐Ochir, Navchaa Gombodorj, Ayaka Katayama, Tetsunari Oyama, Ken Shirabe, Hiroyuki Kuwano, Hiroshi Saeki
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Cancer Reports
Subjects:
CD8+ T‐lymphocytes
colorectal neoplasms
LOX‐1
macrophage
myeloid‐derived suppressor cells
prognosis
Online Access:https://doi.org/10.1002/cnr2.1364

Internet

https://doi.org/10.1002/cnr2.1364

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