MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis

MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis

IntroductionVisceral leishmaniasis (VL) is an important tropical and neglected disease and represents a serious global health problem. The initial interaction between the phagocytes and the parasite is crucial to determine the pathogen’s capacity to initiate infection and it shapes the subsequent im...

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Main Authors: Luana Oliveira Borges-Fernandes, Marcela de Lima Moreira, Victória Hellena Silva Pereira, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Ismael Artur da Costa-Rocha, Ludmila Rosa Lopes, Guilherme Telles Cristo Moreira, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Joaquim Pedro Brito-de-Sousa, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Moriya Tsuji, Olindo Assis Martins-Filho, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
MR1 blockade
L. infantum
phagocytes
soluble mediators
integrative circuits
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1373498/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1373498/full

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