IDO/kynurenine pathway in cancer: possible therapeutic approaches
Abstract Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis, recurrence, and chemoresistance is the change in the tumor immune microenvironment, especially immunosuppression. Cancer immunosuppression ap...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-022-03554-w |
| _version_ | 1818505206391898112 |
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| author | Eslam E. Abd El-Fattah |
| author_facet | Eslam E. Abd El-Fattah |
| author_sort | Eslam E. Abd El-Fattah |
| collection | DOAJ |
| description | Abstract Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis, recurrence, and chemoresistance is the change in the tumor immune microenvironment, especially immunosuppression. Cancer immunosuppression appears in multiple forms, such as inhibition of immuno-stimulant cells with downregulation of immuno-stimulant mediators or through stimulation of immuno-suppressive cells with upregulation of immunosuppressive mediators. One of the most immunosuppressive mediators that approved potency in lung cancer progression is indoleamine 2,3-dioxygenase (IDO) and its metabolite kynurenine (Kyn). The current review tries to elucidate the role of IDO/Kyn on cancer proliferation, apoptosis, angiogenesis, oxidative stress, and cancer stemness. Besides, our review investigates the new therapeutic modalities that target IDO/Kyn pathway and thus as drug candidates for targeting lung cancer and drugs that potentiate IDO/Kyn pathway and thus can be cancer-promoting agents. |
| first_indexed | 2024-12-10T21:47:33Z |
| format | Article |
| id | doaj.art-7086dfb2d2ae450fa18d75a7f6d12139 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-10T21:47:33Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-7086dfb2d2ae450fa18d75a7f6d121392022-12-22T01:32:19ZengBMCJournal of Translational Medicine1479-58762022-08-0120111310.1186/s12967-022-03554-wIDO/kynurenine pathway in cancer: possible therapeutic approachesEslam E. Abd El-Fattah0Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and TechnologyAbstract Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis, recurrence, and chemoresistance is the change in the tumor immune microenvironment, especially immunosuppression. Cancer immunosuppression appears in multiple forms, such as inhibition of immuno-stimulant cells with downregulation of immuno-stimulant mediators or through stimulation of immuno-suppressive cells with upregulation of immunosuppressive mediators. One of the most immunosuppressive mediators that approved potency in lung cancer progression is indoleamine 2,3-dioxygenase (IDO) and its metabolite kynurenine (Kyn). The current review tries to elucidate the role of IDO/Kyn on cancer proliferation, apoptosis, angiogenesis, oxidative stress, and cancer stemness. Besides, our review investigates the new therapeutic modalities that target IDO/Kyn pathway and thus as drug candidates for targeting lung cancer and drugs that potentiate IDO/Kyn pathway and thus can be cancer-promoting agents.https://doi.org/10.1186/s12967-022-03554-wIndoleamine 2,3-dioxygenaseKynurenineLung cancerIDO/kynurenine inhibitorsIDO/kynurenine stimulator |
| spellingShingle | Eslam E. Abd El-Fattah IDO/kynurenine pathway in cancer: possible therapeutic approaches Journal of Translational Medicine Indoleamine 2,3-dioxygenase Kynurenine Lung cancer IDO/kynurenine inhibitors IDO/kynurenine stimulator |
| title | IDO/kynurenine pathway in cancer: possible therapeutic approaches |
| title_full | IDO/kynurenine pathway in cancer: possible therapeutic approaches |
| title_fullStr | IDO/kynurenine pathway in cancer: possible therapeutic approaches |
| title_full_unstemmed | IDO/kynurenine pathway in cancer: possible therapeutic approaches |
| title_short | IDO/kynurenine pathway in cancer: possible therapeutic approaches |
| title_sort | ido kynurenine pathway in cancer possible therapeutic approaches |
| topic | Indoleamine 2,3-dioxygenase Kynurenine Lung cancer IDO/kynurenine inhibitors IDO/kynurenine stimulator |
| url | https://doi.org/10.1186/s12967-022-03554-w |
| work_keys_str_mv | AT eslameabdelfattah idokynureninepathwayincancerpossibletherapeuticapproaches |