The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.

The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal. The fusion p...

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Bibliographic Details
Main Authors: Rosalind Codrington, Richard Pannell, Alan Forster, Lesley F Drynan, Angelika Daser, Nati Lobato, Markus Metzler, Terence H Rabbitts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1159166?pdf=render

Internet

http://europepmc.org/articles/PMC1159166?pdf=render

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