Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles

Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles

A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential antiplasmodium activity against a multidrug-resistant K1 strain an...

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Bibliographic Details
Main Authors: Matshawandile Tukulula, Stefan Louw, Mathew Njoroge, Kelly Chibale
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
human African trypanosomiasis (HAT)
<i>Plasmodium falciparum</i> chloroquine multidrug-resistant (K1) strain
4-aminoquinoline β-lactams
8-aminoquinoline tetrazoles
aqueous kinetic solubility
Online Access:https://www.mdpi.com/1420-3049/25/24/5941

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https://www.mdpi.com/1420-3049/25/24/5941

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