Integrating transcriptomics and metabolomics to elucidate the mechanism by which taurine protects against DOX-induced depression

Abstract Doxorubicin (DOX) is an effective anticancer drug with potent antitumour activity. However, the application of DOX is limited by its adverse reactions, such as depression. Taurine can alleviate depression induced by multiple factors. However, it is still unclear whether and how taurine impr...

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Bibliographic Details
Main Authors: Yanan Li, Luxi Li, Shanshan Wei, Jia Yao, Benhui Liang, Xue Chu, Lei Wang, Hui Liu, Dehua Liao, Daotong Liu, Pei Jiang
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-51138-5