Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways, and genes present across the spectrum of histopathological damage in COVID-19–...

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Bibliographic Details
Main Authors: Amy R. Cross, Carlos E. de Andrea, María Villalba-Esparza, Manuel F. Landecho, Lucia Cerundolo, Praveen Weeratunga, Rachel E. Etherington, Laura Denney, Graham Ogg, Ling-Pei Ho, Ian S.D. Roberts, Joanna Hester, Paul Klenerman, Ignacio Melero, Stephen N. Sansom, Fadi Issa
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-01-01
Series:JCI Insight
Subjects:
COVID-19
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.157837

Internet

https://doi.org/10.1172/jci.insight.157837

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