Low doses of Perampanel protect striatal and hippocampal neurons against in vitro ischemia by reversing the ischemia-induced alteration of AMPA receptor subunit composition

Low doses of Perampanel protect striatal and hippocampal neurons against in vitro ischemia by reversing the ischemia-induced alteration of AMPA receptor subunit composition

Energy depletion caused by ischemic brain insults may result in persistent neuronal depolarization accompanied by hyper-stimulation of ionotropic glutamate receptors and excitotoxic phenomena, possibly leading to cell death. The use of glutamate receptor antagonists, such as the AMPARs antagonist Pe...

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Bibliographic Details
Main Authors: Petra Mazzocchetti, Andrea Mancini, Miriam Sciaccaluga, Alfredo Megaro, Laura Bellingacci, Massimiliano Di Filippo, Elena Nardi Cesarini, Michele Romoli, Nicolò Carrano, Fabrizio Gardoni, Alessandro Tozzi, Paolo Calabresi, Cinzia Costa
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Neuroprotection
Oxygen and glucose deprivation
GluA1 AMPA receptor subunit
Ischemic LTP
Striatum
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301236

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http://www.sciencedirect.com/science/article/pii/S0969996120301236

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