Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells

Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells

Abstract Background Abnormal pre-mRNA splicing regulation is common in cancer, but the effects of chemotherapy on this process remain unclear. Methods To evaluate the effect of chemotherapy on slicing regulation, we performed meta-analyses of previously published transcriptomic, proteomic, phosphopr...

Full description

Bibliographic Details
Main Authors: Ksenia S. Anufrieva, Victoria О. Shender, Georgij P. Arapidi, Marat S. Pavlyukov, Michail I. Shakhparonov, Polina V. Shnaider, Ivan O. Butenko, Maria A. Lagarkova, Vadim M. Govorun
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Genome Medicine
Subjects:
Alternative splicing
Cell cycle
Chemotherapy
DNA damage response
Spliceosome
Pladienolide B
Online Access:http://link.springer.com/article/10.1186/s13073-018-0557-y

Internet

http://link.springer.com/article/10.1186/s13073-018-0557-y

Similar Items