Safety, Tolerability, and Pharmacokinetics of a Novel Human Hepatitis B Virus Capsid Assembly Modulator Canocapavir: A Randomized First-in-Human Study

Safety, Tolerability, and Pharmacokinetics of a Novel Human Hepatitis B Virus Capsid Assembly Modulator Canocapavir: A Randomized First-in-Human Study

Background and Aims: Canocapavir (ZM-H1505R) is a small-molecule hepatitis B virus capsid assembly modulator with a novel pyrazole structure. This is the first-in-human study to investigate its safety, tolerability, and pharmacokinetics (PK) following oral administration in healthy subjects. Methods...

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Bibliographic Details
Main Authors: Xiuhong Jiang, Bo Hua, Gang Liu, Tian Xia, Aiyun Deng, Hui Lu, Ruoling Guo, Zhe Wang, Bo Liang, Huanming Chen, Qiu Jin, Zhijun Zhang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Gastro Hep Advances
Subjects:
Canocapavir
HBV
Capsid assembly modulator
First-in-human
Online Access:http://www.sciencedirect.com/science/article/pii/S2772572323000018

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http://www.sciencedirect.com/science/article/pii/S2772572323000018

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