High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer

High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer

Abstract Purpose Cancer cells require a supply of amino acids, particularly essential amino acids such as branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine), to meet the increased nutrient demands of malignant tumors. The cell-autonomous and non-autonomous roles of altered BCA...

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Bibliographic Details
Main Authors: Haiqing Wang, Sen Chen, Wenhui Kang, Bojiao Ding, Shulan Cui, Li Zhou, Na Zhang, Huiying Luo, Mingjuan Wang, Fan Zhang, Zezhou Zhao, Zihu Guo, Chao Wang, Liang Li, Zhengzhong Wang, Xuetong Chen, Yonghua Wang
Format: Article
Language:English
Published: Springer 2023-02-01
Series:Discover Oncology
Subjects:
Branched-chain amino acids
Isoleucine
Tumor therapy
PTEN
IARS
Online Access:https://doi.org/10.1007/s12672-023-00634-1

Internet

https://doi.org/10.1007/s12672-023-00634-1

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