Dityrosine cross-linking and its potential roles in Alzheimer’s disease
Oxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer’s disease (AD) pathogenesis. Oxidation of proteins can give rise to covalent links between adjacent tyrosines known as dityrosine (DiY) cross-linking, amongst other modifications, and this o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1132670/full |
| _version_ | 1827985767182368768 |
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| author | Mahmoud B. Maina Mahmoud B. Maina Youssra K. Al-Hilaly Youssra K. Al-Hilaly Louise C. Serpell |
| author_facet | Mahmoud B. Maina Mahmoud B. Maina Youssra K. Al-Hilaly Youssra K. Al-Hilaly Louise C. Serpell |
| author_sort | Mahmoud B. Maina |
| collection | DOAJ |
| description | Oxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer’s disease (AD) pathogenesis. Oxidation of proteins can give rise to covalent links between adjacent tyrosines known as dityrosine (DiY) cross-linking, amongst other modifications, and this observation suggests that DiY could serve as a biomarker of accumulated oxidative stress over the lifespan. Many studies have focused on understanding the contribution of DiY to AD pathogenesis and have revealed that DiY crosslinks can be found in both Aβ and tau deposits – the two key proteins involved in the formation of amyloid plaques and tau tangles, respectively. However, there is no consensus yet in the field on the impact of DiY on Aβ and tau function, aggregation, and toxicity. Here we review the current understanding of the role of DiY on Aβ and tau gathered over the last 20 years since the first observation, and discuss the effect of this modification for Aβ and tau aggregation, and its potential as a biomarker for AD. |
| first_indexed | 2024-04-09T23:19:42Z |
| format | Article |
| id | doaj.art-70a09f36edf04aff9cce76085be19d7f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T23:19:42Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-70a09f36edf04aff9cce76085be19d7f2023-03-22T04:31:33ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11326701132670Dityrosine cross-linking and its potential roles in Alzheimer’s diseaseMahmoud B. Maina0Mahmoud B. Maina1Youssra K. Al-Hilaly2Youssra K. Al-Hilaly3Louise C. Serpell4Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, United KingdomBiomedical Science Research and Training Centre, College of Medical Sciences, Yobe State University, Damaturu, NigeriaSussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, United KingdomDepartment of Chemistry, College of Science, Mustansiriyah University, Baghdad, IraqSussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, United KingdomOxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer’s disease (AD) pathogenesis. Oxidation of proteins can give rise to covalent links between adjacent tyrosines known as dityrosine (DiY) cross-linking, amongst other modifications, and this observation suggests that DiY could serve as a biomarker of accumulated oxidative stress over the lifespan. Many studies have focused on understanding the contribution of DiY to AD pathogenesis and have revealed that DiY crosslinks can be found in both Aβ and tau deposits – the two key proteins involved in the formation of amyloid plaques and tau tangles, respectively. However, there is no consensus yet in the field on the impact of DiY on Aβ and tau function, aggregation, and toxicity. Here we review the current understanding of the role of DiY on Aβ and tau gathered over the last 20 years since the first observation, and discuss the effect of this modification for Aβ and tau aggregation, and its potential as a biomarker for AD.https://www.frontiersin.org/articles/10.3389/fnins.2023.1132670/fullAlzheimer’s diseaseamyloid-betatauoxidativedityrosine |
| spellingShingle | Mahmoud B. Maina Mahmoud B. Maina Youssra K. Al-Hilaly Youssra K. Al-Hilaly Louise C. Serpell Dityrosine cross-linking and its potential roles in Alzheimer’s disease Frontiers in Neuroscience Alzheimer’s disease amyloid-beta tau oxidative dityrosine |
| title | Dityrosine cross-linking and its potential roles in Alzheimer’s disease |
| title_full | Dityrosine cross-linking and its potential roles in Alzheimer’s disease |
| title_fullStr | Dityrosine cross-linking and its potential roles in Alzheimer’s disease |
| title_full_unstemmed | Dityrosine cross-linking and its potential roles in Alzheimer’s disease |
| title_short | Dityrosine cross-linking and its potential roles in Alzheimer’s disease |
| title_sort | dityrosine cross linking and its potential roles in alzheimer s disease |
| topic | Alzheimer’s disease amyloid-beta tau oxidative dityrosine |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1132670/full |
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