Extracellular glucose levels in cultures of undifferentiated mouse trophoblast stem cells affect gene expression during subsequent differentiation with replicable cell line-dependent variation

Mouse trophoblast stem cells (TSCs) have been established and maintained using hyperglycemic conditions (11 mM glucose) for no apparent good reason. Because glucose metabolites are used as resources for cellular energy production, biosynthesis, and epigenetic modifications, differences in extracellu...

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Bibliographic Details
Main Authors: Kenta NISHITANI, Koji HAYAKAWA, Satoshi TANAKA
Format: Article
Language:English
Published: The Society for Reproduction and Development 2018-10-01
Series:The Journal of Reproduction and Development
Subjects:
Online Access:https://www.jstage.jst.go.jp/article/jrd/65/1/65_2018-083/_pdf/-char/en