Imputation of single-cell transcriptome data enables the reconstruction of networks predictive of breast cancer metastasis

Imputation of single-cell transcriptome data enables the reconstruction of networks predictive of breast cancer metastasis

Single-cell transcriptome data provide a unique opportunity to explore the gene networks of a particular cell type. However, insufficient capture rate and high dimensionality of single-cell RNA sequencing (scRNA-seq) data challenge cell-type-specific gene network (CGN) reconstruction. Here, we demon...

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Bibliographic Details
Main Authors: Junha Cha, Michael Lavi, Junhan Kim, Noam Shomron, Insuk Lee
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Single-cell RNA sequencing
Imputation
Single cell network biology
Cell-type-specific gene network
Metastasis
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023001344

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http://www.sciencedirect.com/science/article/pii/S2001037023001344

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