ECPPF (E2F1, CCNA2, POLE, PPP2R1A, FBXW7) stratification: Profiling high-risk subtypes of histomorphologically low-risk and treatment-insensitive endometrioid endometrial cancer.

ECPPF (E2F1, CCNA2, POLE, PPP2R1A, FBXW7) stratification: Profiling high-risk subtypes of histomorphologically low-risk and treatment-insensitive endometrioid endometrial cancer.

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In endometrial cancer, occult high-risk subtypes (rooted in histomorphologically low-risk disease) with insensitivity to adjuvant therapies impede improvements in therapeutic efficacy. Therefore, we aimed to assess the ability of molecular high-risk (MHR) and low-risk (MLR) ECPPF (E2F1, CCNA2, POLE,...

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Bibliographic Details
Main Authors: Jesus Gonzalez-Bosquet, S John Weroha, Jamie N Bakkum-Gamez, Amy L Weaver, Michaela E McGree, Sean C Dowdy, Abimbola O Famuyide, Benjamin R Kipp, Kevin C Halling, Siddhartha Yadav, Fergus J Couch, Karl C Podratz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0278408

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https://doi.org/10.1371/journal.pone.0278408

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