Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein in the minor allele AGT-LM that contains the P11L polymorphism, which may affect the folding of the N-terminal segment (NTT-AGT). The NTT-AGT...

Full description

Bibliographic Details
Main Authors: Jose L. Neira, Athi N. Naganathan, Noel Mesa-Torres, Eduardo Salido, Angel L. Pey
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
conformational landscape
spectroscopy
circular dichroism
NMR
phosphorylation
mutation
Online Access:https://www.mdpi.com/1420-3049/27/24/8762

Internet

https://www.mdpi.com/1420-3049/27/24/8762

Similar Items