Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development

Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development

BackgroundMerTK is a tyrosine kinase receptor that belongs to the TAM (Tyro3/Axl/Mer) receptor family. It is involved in different processes including cellular proliferation/survival, cellular adhesion/migration, and release of the inflammatory/anti-inflammatory cytokines. Although it is reported th...

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Bibliographic Details
Main Authors: Rosaria Maria Pipitone, Vincenza Calvaruso, Lorenza Di Marco, Francesca Di Salvo, Miriam Gaggianesi, Giulia Lupo, Rossella Zito, Claudia La Mantia, Matteo Ramazzotti, Salvatore Petta, Vito Di Marco, Antonio Craxì, Stefania Grimaudo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
Mer Tyrosine Kinase polymorphism (MERTK polymorphism)
liver fibrosis
hepatocellular carcinoma
matrix metallopeptidase
WNT gene family pathway (WNT pathway)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.926236/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.926236/full

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