PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer

PTENα is an N-terminally extended isoform of PTEN, a gene frequently mutated in human cancers. Here the authors show that PTENα remains active in PTEN-mutant cancers and is associated with tumor immune escape by promoting tumor cell resistance to T cell cytotoxicity.

Bibliographic Details
Main Authors: Yizhe Sun, Dan Lu, Yue Yin, Jia Song, Yang Liu, Wenyan Hao, Fang Qi, Guangze Zhang, Xin Zhang, Liang Liu, Zhiqiang Lin, Hui Liang, Xuyang Zhao, Yan Jin, Yuxin Yin
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25417-6

Internet

https://doi.org/10.1038/s41467-021-25417-6

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