Identification of highly reliable risk genes for Alzheimer’s disease through joint-tissue integrative analysis

Identification of highly reliable risk genes for Alzheimer’s disease through joint-tissue integrative analysis

Numerous genetic variants associated with Alzheimer’s disease (AD) have been identified through genome-wide association studies (GWAS), but their interpretation is hindered by the strong linkage disequilibrium (LD) among the variants, making it difficult to identify the causal variants directly. To...

Full description

Bibliographic Details
Main Authors: Yong Heng Wang, Pan Pan Luo, Ao Yi Geng, Xinwei Li, Tai-Hang Liu, Yi Jie He, Lin Huang, Ya Qin Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
GWAS
TWAS
Mendelian Randomization
eQTL
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1183119/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1183119/full

Similar Items