Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

Abstract Background Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead to the ventilator- induced diaphragm dysfunction. Especially, it is critical in older adults who have lower muscle reparative capacity follow...

Full description

Bibliographic Details
Main Authors: Robert T. Mankowski, Shakeel Ahmed, Thomas Beaver, Marvin Dirain, Chul Han, Phillip Hess, Tomas Martin, Barbara K. Smith, Shinichi Someya, Christiaan Leeuwenburgh, A. Daniel Martin
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Journal of Translational Medicine
Subjects:
Electrical Stimulation
Mitochondrial Biogenesis
Phrenic Nerve
Oxidative Stress Level
Autophagy Flux
Online Access:http://link.springer.com/article/10.1186/s12967-016-1060-0

Internet

http://link.springer.com/article/10.1186/s12967-016-1060-0

Similar Items