Deletion of Glycogen Synthase Kinase 3 Beta Reprograms NK Cell Metabolism

Deletion of Glycogen Synthase Kinase 3 Beta Reprograms NK Cell Metabolism

Loss of cytotoxicity and defective metabolism are linked to glycogen synthase kinase 3 beta (GSK3β) overexpression in natural killer (NK) cells from patients with acute myeloid leukemia or from healthy donors after expansion ex vivo with IL-15. Drug inhibition of GSK3β in these NK cells improves the...

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Bibliographic Details
Main Authors: Marcelo S. F. Pereira, Kinnari Sorathia, Yasemin Sezgin, Aarohi Thakkar, Colin Maguire, Patrick L. Collins, Bethany L. Mundy-Bosse, Dean A. Lee, Meisam Naeimi Kararoudi
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
natural killer cells
NK cells
GSK3β
AML
Cas9/RNP
CRISPR
Online Access:https://www.mdpi.com/2072-6694/15/3/705

Internet

https://www.mdpi.com/2072-6694/15/3/705

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