Facile and Stereoselective Synthesis of Non-Racemic 3,3,3-Trifluoroalanine

Facile and Stereoselective Synthesis of Non-Racemic 3,3,3-Trifluoroalanine

A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfi...

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Bibliographic Details
Main Authors: Matteo Zanda, Alessandro Volonterio, Pierfrancesco Bravo, Natalia Battista, Marcello Crucianelli
Format: Article
Language:English
Published: MDPI AG 2000-12-01
Series:Molecules
Subjects:
Fluorine
Amino acids
Sulfinimines
Asymmetric synthesis
Online Access:http://www.mdpi.com/1420-3049/5/12/1251/

Internet

http://www.mdpi.com/1420-3049/5/12/1251/

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