Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Abstract M3 muscarinic receptors (M3R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico, in vitro, and in vivo approaches, we explored whether...

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Bibliographic Details
Main Authors: Kunrong Cheng, Ahmed Chahdi, Shannon M. Larabee, Mazen Tolaymat, Margaret H. Sundel, Cinthia B. Drachenberg, Min Zhan, Shien Hu, Anan H. Said, Aaron C. Shang, Guofeng Xie, Madeline Alizadeh, Natalia Sampaio Moura, Andrea C. Bafford, Richelle T. Williams, Nader N. Hanna, Jean-Pierre Raufman
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44158-8

Internet

https://doi.org/10.1038/s41598-023-44158-8

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